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Propylene Glycol Diisostearate
AKA “68958-54-3, EINECS 273-373-2, Isooctadecanoic acid, 1-methyl-1, 2-ethanediyl ester, 1, 1'-(1-methyl-1, 2-ethanediyl) ester, RefChem:149635, 1-Methyl-1, 2-ethanediyl diisooctadecanoate, propane-1, 2-diyl bis(16-methylheptadecanoate), 2-(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate, SCHEMBL480236”
Emollient
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Ingredient Facts
Propylene glycol diisostearate
AKA: 68958-54-3, EINECS 273-373-2, Isooctadecanoic acid, 1-methyl-1, 2-ethanediyl ester, 1, 1'-(1-methyl-1, 2-ethanediyl) ester, RefChem:149635, 1-Methyl-1, 2-ethanediyl diisooctadecanoate, Propane-1, 2-diyl bis(16-methylheptadecanoate), 2-(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate, SCHEMBL480236
Emollient · Emollient · EWG: 4
Plant-Derived
Emollient
Skin Conditioner
Plant Oil
Not Clean
1-Methyl-1,2-ethanediyl diisooctadecanoate
Effective at 1.0%
Formula
C39H76O4
Mol. Weight
609.00
CAS #
68958-54-3
Form
Liquid
See origin →
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
Traditional Use
Developed in the late 20th century as a propylene glycol diester of isostearic acid. Used in contemporary cosmetics as an emollient and thickening agent, designed to provide conditioning similar to natural fatty acids with improved stability.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
9.9e-05%
2.0%
0%14%
Effective Range
CIR reported use: 0.000099-2
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Addendum to the Final Report on the Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol (JEPT 4(4) 47-61 1980)
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report of the Safety Assessment for 2-Bromo-2-Nitropropane-1,3-Diol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Revised Tentative Report: Amended Safety Assessment of 2-Bromo-2-Nitropropane-1,3-Diol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
2-Bromo-2-Nitropropane-1,3-Diol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Propylene Glycol Diisostearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
2-Bromo-2-Nitropropane-1,3-Diol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
PROPANE-1
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
The Additive Influence of Propane-1,2-Diol on SDS Micellar Structure and Properties.
Gudelj M, Šurina P, Jurko L, Prkić A, Bošković P
Molecules (Basel, Switzerland), 2021
→
2-Bromo-2-nitropropane-1,3-diol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Kitty Litter Dermatitis from-Bromo-2-Nitropropane-1,3-Diol.
Sullenbarger JW, Hensley B, Travers JB
Skinmed, 2017
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR