Pentylene Glycol
AKA “1, 2-Pentanediol, 5343-92-0, 2-Dihydroxypentane, NSC-513, 50C1307PZG, DTXSID10863522, RefChem:860099, DTXCID80812123, 226-285-3”
Skin Conditioning
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Ingredient Facts
Pentylene glycol
AKA: 1, 2-Pentanediol, 5343-92-0, 2-Dihydroxypentane, NSC-513, 50C1307PZG, DTXSID10863522, RefChem:860099, DTXCID80812123, 226-285-3
Skin Conditioning · Skin Conditioning · EWG: 2
Synthetic
Solvent
Skin Conditioner
Clean
structure in first source
Effective at 2.5%
Formula
C5H12O2
Mol. Weight
104.15
CAS #
5343-92-0
Form
Liquid
State
Liquid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks in moisture
Traditional Use
A synthetic humectant and preservative booster developed in the late 20th century. Created to improve hydration and product stability in modern skincare formulations.
Skin Types
●all-skin-types, gentle
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
ewg-2
medical-approval
pregnancy-nursing-safe
all-shades-safe
Potential Sensitizer
Concentration Guide
0.005%
5.0%
0%7%
Effective Range
CIR reported use: 0.3-5 | 0.005-4
Regulatory Agencies
3 Piece Classic Suncare Travel Set
COOLA
advanced retinol gel 0.5%
Cocokind
the anti aging day and night ritual
Agent Nateur
AHA Exfoliating Solution
Indie Lee
beginner retinol gel 0.1%
Cocokind
Black Tulip Eye Treatment
Bloom Effects
Bonne Nuit™ Night Cream
Pai Skincare
Brightening Cream
Indie Lee
calm & clarify duo
Cocokind
Hydrating Sunscreen Lotion - Peach Blossom
COOLA
Clean & Comfort Duo
Indie Lee
travel-size Electrolyte Water Cream
Cocokind
Double Cleanse for Balanced & Combo Skin
Indie Lee
Double Cleanse for Dry or Mature Skin
Indie Lee
Energize Body Cleanser (50mL)
Grown Alchemist
Everyday Radiance Essentials
Bloom Effects
Fade Forward™ Serum
Pai Skincare
Spectator Sport Mascara
Gen See
Gentle Daily Peel
Indie Lee
Golden Hour Body Serum
Ursa Major
Skin Defense Primer
Grown Alchemist
holi (lift) ageless lifting and firming serum deluxe mini
Agent Nateur
Hyaluronic Acid 0.3% Hydrating Booster
Pai Skincare
hydration heroes set
Cocokind
Clean Line Liquid Liner
ILIA Beauty
Liquid Powder Eye Tint
ILIA Beauty
True Skin Serum Foundation
ILIA Beauty
Air Brow - Tinted
Kosas
BB Burst
Kosas
GrowPotion
Kosas
Revealer Concealer
Kosas
Revealer Skin-Improving Foundation SPF 25
Kosas
Shiny Objects
Kosas
lactic acid cleanser duo
Agent Nateur
Lunar Bloom Retinal Serum
Ursa Major
Making Moves Milky Cleanser
Ursa Major
Meltaway Gel-Milk Cleanser (100mL)
Grown Alchemist
Mountain Glow Serum
Ursa Major
peptide fine line eye gel
Cocokind
Phytofill™ 1% Firming Booster
Pai Skincare
Purifying Face Wash
Indie Lee
Radiance Reset
Bloom Effects
retinol face + body duo
Cocokind
Revitalize Hand Wash (500mL)
Grown Alchemist
Rewakening™ Rosewater Mist
COOLA
rise + shine trio
Cocokind
Master Radiance Base
RMS Beauty
ReDimension Hydra Bronzer
RMS Beauty
ReDimension Hydra Dew Luminizer
RMS Beauty
ReDimension Hydra Powder Blush
RMS Beauty
Pentylene Glycol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Pentylene Glycol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Margin of safety of pentylene glycol derived using measurements of cutaneous absorption and volatility.
Steiner A, Kugarajan K, Wullimann M, Ruty B, Kunze G
Regulatory toxicology and pharmacology : RTP, 2017
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR