Hydroxypropyl Cyclodextrin
AKA “RefChem:789549”
Skin Conditioning
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Ingredient Facts
Hydroxypropyl cyclodextrin
AKA: RefChem:789549
Skin Conditioning · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Clean
.beta.-Cyclodextrin, 2-hydroxypropyl ethers
Formula
C39H66O31
Mol. Weight
1030.90
CAS #
128446-33-3, 128446-35-5
Form
Powder
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
Developed in the late 20th century as a synthetic solubilizing agent derived from cyclodextrin technology. Used in cosmetics to improve the bioavailability and stability of poorly soluble active ingredients.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Dermal absorption: 2%. Source: CIR Safety Assessment (CIR Seq 680).
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR