Calcium Disodium EDTA
AKA “Edetate calcium disodium, EDTA calcium disodium, Detoxamin, Edetate calcium disodium anhydrous, Calcium disodium ethylenediaminetetraacetate, INS NO.385, DTXSID2036409, INS-385, Edetate Calcium Disodium (anhydrous), NSC-310151”
Ingredient
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Ingredient Facts
Calcium disodium edta
AKA: Edetate calcium disodium, EDTA calcium disodium, Detoxamin, Edetate calcium disodium anhydrous, Calcium disodium ethylenediaminetetraacetate, INS NO.385, DTXSID2036409, INS-385, Edetate Calcium Disodium (anhydrous), NSC-310151
Ingredient · Chelating · EWG: 1
Synthetic
Chelating Agent
Clean
Calciate(2-), [[N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',O(N)-,O(N')-]-, disodium
Solubility Powder. Solubility in water: at 20 °C a 0.1M solution can be prepared (pH approx 7). Pratically insoluble in organic solvents /Tetrahydrate/
Formula
C10H12CaN2Na2O8
Mol. Weight
374.27
CAS #
62-33-9
Form
Powder
State
Pellets or Large Crystals; Liquid, Other Solid; Other Solid; Liquid; Dry Powder
See origin →
Functions
Chelating
Grabs onto metal ions in water that would destabilize the formula. Keeps your product from going bad or changing color.
Removes Metal Ions
Reduces Inflammation
Fights Bacteria
Wound Healing
Binds metal ions
Traditional Use
EDTA (ethylenediaminetetraacetic acid) was synthesized in 1935 as a chelating agent. Adopted by cosmetics in the mid-20th century to improve product stability by binding metal ions that cause oxidation and discoloration.
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
1
CIR
Reviewed by CIR
Pregnancy
Caution
CIR Safety Findings
ewg-1
pregnancy-nursing-safe
all-shades-safe
Regulatory Agencies
Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, and Trisod
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Calcium Disodium EDTA
European Commission
EU Cosmetic Ingredient Database (CosIng)
Calcium Disodium EDTA
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tr
Lanigan RS, Yamarik TA
International journal of toxicology, 2002
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR