undefined 1
undefined 2
undefined 3
undefined 4
undefined 5
Allantoin Glycyrrhetinic Acid
AKA “H6FL381368, UNII-H6FL381368, 4572-09-2, ALLANTOIN, MONO(3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), UREA, (2, 5-DIOXO-4-IMIDAZOLIDINYL)-, MONO((3.BETA., 20.BETA.)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OATE), RefChem:110745, ALLANTOIN GLYCYRRHETINIC ACID [INCI], MONO(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), OLEAN-12-EN-30-OIC ACID, 3BETA-HYDROXY-11-OXO-, COMPD. WITH ALLANTOIN”
Acid
Make this about you

Tap what applies — every card instantly flags it for you. Stays on your device, syncs if you're signed in.

Ingredient Facts
Allantoin glycyrrhetinic acid
AKA: H6FL381368, UNII-H6FL381368, 4572-09-2, MONO(3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), UREA, (2, 5-DIOXO-4-IMIDAZOLIDINYL)-, MONO((3.BETA., 20.BETA.)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OATE), RefChem:110745, ALLANTOIN GLYCYRRHETINIC ACID [INCI], MONO(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), OLEAN-12-EN-30-OIC ACID, 3BETA-HYDROXY-11-OXO-, COMPD. WITH ALLANTOIN
Acid · Soothing · EWG: 1
Synthetic
Soothing
Barrier Support
Wound Healer
Acid
Clean
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta., 20.beta.)-, compound with (2,5-dioxo-4-imidazolydinyl)urea (1:1)
Formula
C34H52N4O7
Mol. Weight
628.80
CAS #
4572-09-2
Form
Liquid
State
Solid
See origin →
Functions
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Nourishing
Protecting
Traditional Use
Combines allantoin (traditional comfrey derivative for skin healing) with glycyrrhetinic acid (the active compound from licorice root, used for centuries in Ayurvedic and Chinese medicine for inflammation). Developed to maximize soothing and conditioning benefits.
Skin Types
●all-skin-types, gentle
Best For
Redness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Irritant
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Concentration Guide
2%
0%3%
Reg. Limit
FDA OTC limit: 2% (Skin Protectant). Source: FDA OTC Monograph, 21 CFR 347.10. Dermal absorption: 10%. Source: CIR Safety Assessment (CIR Seq 310).
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
beginner retinol gel 0.1%
Cocokind
 →
Black Tulip Regenerative Brightening Serum
Bloom Effects
 →
Daily Acid Toner
Josh Rosebrook
 →
Everyday Radiance Essentials
Bloom Effects
 →
Gentle Body Wash - Unscented
Kinship
 →
Gentle Body Wash - Vanilla
Kinship
 →
holi (sun) spf 50 dewy tinted skin drops
Agent Nateur
 →
holi (soleil) firming & plumping mineral spf 50 sunscreen
Agent Nateur
 →
Super Serum Skin Tint SPF 30
ILIA Beauty
 →
lactic acid cleanser duo
Agent Nateur
 →
Making Moves Milky Cleanser
Ursa Major
 →
Moisturizing Body Cream - Unscented
Kinship
 →
Moisturizing Body Cream - Vanilla
Kinship
 →
Morning + Night Serum Set
Kinship
 →
Radiance Reset
Bloom Effects
 →
Restorative Body Serum - Unscented
Kinship
 →
Restorative Body Serum - Vanilla
Kinship
 →
ReFresh Eye Brightener Broad Spectrum SPF 30 + Correcting Tint
RMS Beauty
 →
Royal Tulip Hydrating Bi-Phase Tonic
Bloom Effects
 →
Super Serum Skin Tint SPF 40
ILIA Beauty
 →
The ILIA Look
ILIA Beauty
 →
Daily SPF 50 Primer
Indie Lee
 →
DreamBeam SPF 40 PA++++
Kosas
 →
Plump + Juicy Gel Cleanser
Kosas
 →
COLORFREE Zinc Broad Spectrum Sunscreen SPF 32
Credo Beauty
 →
COLORFREE ZINC Broad Spectrum Sunscreen | SPF 32
Marie Veronique
 →
Everyday Coverage Tinted Sunscreen, SPF 30
Credo Beauty
 →
Everyday Coverage Tinted Sunscreen SPF 30
Marie Veronique
 →
ReFresh Eye Brightener SPF 30 + Correcting Tint
RMS Beauty
 →
The Brighten Up Essentials
RMS Beauty
 →
Chebula Multi-Corrective Eye Patches
True Botanicals
 →
Sunlit Essentials Set
Indie Lee
 →
the after (glow) set: rose quartz
Agent Nateur
 →
the after (glow) set: ruby
Agent Nateur
 →
the body duo
Agent Nateur
 →
The Bodycare Ritual - Unscented
Kinship
 →
The Bodycare Ritual - Vanilla
Kinship
 →
the vitamin c and hyaluronic brightening duo
Agent Nateur
 →
Glow + Go Set
Kinship
 →
Tulip Dew Drops
Bloom Effects
 →
Tulip Dew Sunscreen Serum
Bloom Effects
 →
Safety Assessment of Hydroxyethyl Urea as Used in Cosmetics.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2024
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Final report of the safety assessment of allantoin and its related complexes.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2010
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Leonardo Celleno
Dermatologic therapy, 2018
→
Topical urea in skincare: A review.
Celleno L
Dermatologic therapy, 2018
→
Final Report of the Safety Assessment for Imidazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report of the Safety Assessment of Allantoin and its Related Complexes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Diazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Polyoxymethylene Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Imidazolidinyl Urea
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Hydroxyethyl Urea As Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Scientific Literature Review: Safety Assessment of Centaurea cyanus Flower-Derived Ingredients as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Allantoin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Allantoin Ascorbate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Allantoin Biotin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Allantoin Galacturonic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Allantoin Glycyrrhetinic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Allantoin Panthenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Allantoin Polygalacturonic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Diazolidinyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Echinacea Purpurea (echinacea) flower/leaf/stem Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Echinacea Purpurea Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydroxyethyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Imidazolidinyl Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Polyoxymethylene Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Urea
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Influence of excipients on moisturizing effect of urea.
Couteau C, Coiffard LJ, Sébille-Rivain V
Drug development and industrial pharmacy, 2006
→
Allantoin
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Allantoin Glycyrrhetinic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Allantoin Panthenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Diazolidinyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydroxyethyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Imidazolidinyl Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Polyoxymethylene Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Urea
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
1-Butyl-3-(N-crotonoylsulfanilyl) urea
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Claviceps purpurea Tul., its alkaloids and galenical preparations
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Digitalis purpurea L., all heterosides of
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Thiourea and its derivatives
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Urea
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Urea (carbamide) peroxide
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Recombinant scFv-Fc Anti-kallikrein 7 Antibody-Loaded Thermosensitive Hydrogels Against Skin Desquamation Disorders.
Laureano AFS, Vigato AA, Puzer L, de Araujo DR
ACS applied bio materials, 2024
→
Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.
Sanz MT, Campos C, Milani M, Foyaca M, Lamy A et al.
Journal of cosmetic dermatology, 2016
→
Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes.
Stavanja MS, Curtin GM, Ayres PH, Bombick ER, Borgerding MF et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008
→
Allantoin-functionalized silk fibroin/sodium alginate tra...
Haojiang Xie, Qiao Bai, Fankai Kong, Yang Li, Xiaoying Zha, Lingqin Zhang + 4 more
International journal of biological macromolecules, 2022
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR